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Schizoaffective disorder

MedGen UID:
11334
•Concept ID:
C0036337
•
Mental or Behavioral Dysfunction
Synonyms: Disorder, Schizoaffective; Disorders, Schizoaffective; Schizoaffective Disorder; Schizoaffective Disorders
SNOMED CT: Schizoaffective disorder (68890003); Schizoaffective schizophrenia (191567000)
 
Monarch Initiative: MONDO:0005487

Definition

A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSchizoaffective disorder

Professional guidelines

PubMed

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis.
Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235

Recent clinical studies

Etiology

Schizophrenia and Emergency Medicine.
Lawrence RE, Bernstein A
Emerg Med Clin North Am 2024 Feb;42(1):93-104. Epub 2023 Jul 28 doi: 10.1016/j.emc.2023.06.012. PMID: 37977755
Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial.
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
Asymmetric dimethylarginine in psychiatric disorders.
Braun D, Schlossmann J, Haen E
Psychiatry Res 2021 Jun;300:113901. Epub 2021 Mar 23 doi: 10.1016/j.psychres.2021.113901. PMID: 33819866
Life events in schizoaffective disorder: A systematic review.
Vardaxi CC, Gonda X, Fountoulakis KN
J Affect Disord 2018 Feb;227:563-570. Epub 2017 Nov 15 doi: 10.1016/j.jad.2017.11.076. PMID: 29172048
Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder.
Cardno AG, Owen MJ
Schizophr Bull 2014 May;40(3):504-15. Epub 2014 Feb 24 doi: 10.1093/schbul/sbu016. PMID: 24567502Free PMC Article

Diagnosis

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Current Evidences on Psychopharmacology of Schizoaffective Disorder.
Muñoz-Negro JE, Cuadrado L, Cervilla JA
Actas Esp Psiquiatr 2019 Sep;47(5):190-201. Epub 2019 Sep 1 PMID: 31648341
Schizoaffective disorder: A review.
Miller JN, Black DW
Ann Clin Psychiatry 2019 Feb;31(1):47-53. PMID: 30699217
Definition and description of schizophrenia in the DSM-5.
Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):3-10. Epub 2013 Jun 22 doi: 10.1016/j.schres.2013.05.028. PMID: 23800613
Schizoaffective Disorder in the DSM-5.
Malaspina D, Owen MJ, Heckers S, Tandon R, Bustillo J, Schultz S, Barch DM, Gaebel W, Gur RE, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):21-5. Epub 2013 May 23 doi: 10.1016/j.schres.2013.04.026. PMID: 23707642

Therapy

Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial.
Sethi S, Wakeham D, Ketter T, Hooshmand F, Bjornstad J, Richards B, Westman E, Krauss RM, Saslow L
Psychiatry Res 2024 May;335:115866. Epub 2024 Mar 20 doi: 10.1016/j.psychres.2024.115866. PMID: 38547601
Efficacy and effectiveness of antipsychotics in schizophrenia: network meta-analyses combining evidence from randomised controlled trials and real-world data.
Efthimiou O, Taipale H, Radua J, Schneider-Thoma J, Pinzón-Espinosa J, Ortuño M, Vinkers CH, Mittendorfer-Rutz E, Cardoner N, Tanskanen A, Fusar-Poli P, Cipriani A, Vieta E, Leucht S, Tiihonen J, Luykx JJ
Lancet Psychiatry 2024 Feb;11(2):102-111. Epub 2024 Jan 9 doi: 10.1016/S2215-0366(23)00366-8. PMID: 38215784
Current Evidences on Psychopharmacology of Schizoaffective Disorder.
Muñoz-Negro JE, Cuadrado L, Cervilla JA
Actas Esp Psiquiatr 2019 Sep;47(5):190-201. Epub 2019 Sep 1 PMID: 31648341
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article
KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia.
Hauser RA, Factor SA, Marder SR, Knesevich MA, Ramirez PM, Jimenez R, Burke J, Liang GS, O'Brien CF
Am J Psychiatry 2017 May 1;174(5):476-484. Epub 2017 Mar 21 doi: 10.1176/appi.ajp.2017.16091037. PMID: 28320223

Prognosis

Electrocardiographic abnormalities and psychotropic polypharmacy in schizophrenia and schizoaffective disorders.
Tirupati S, Gulati S
Australas Psychiatry 2022 Apr;30(2):243-246. Epub 2021 Nov 27 doi: 10.1177/10398562211047462. PMID: 34839745
Alcohol Use Disorder and Schizophrenia or Schizoaffective Disorder.
Archibald L, Brunette MF, Wallin DJ, Green AI
Alcohol Res 2019;40(1) Epub 2019 Dec 20 doi: 10.35946/arcr.v40.1.06. PMID: 31886105Free PMC Article
Life events in schizoaffective disorder: A systematic review.
Vardaxi CC, Gonda X, Fountoulakis KN
J Affect Disord 2018 Feb;227:563-570. Epub 2017 Nov 15 doi: 10.1016/j.jad.2017.11.076. PMID: 29172048
Definition and description of schizophrenia in the DSM-5.
Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):3-10. Epub 2013 Jun 22 doi: 10.1016/j.schres.2013.05.028. PMID: 23800613
Schizoaffective Disorder in the DSM-5.
Malaspina D, Owen MJ, Heckers S, Tandon R, Bustillo J, Schultz S, Barch DM, Gaebel W, Gur RE, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):21-5. Epub 2013 May 23 doi: 10.1016/j.schres.2013.04.026. PMID: 23707642

Clinical prediction guides

Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial.
Sethi S, Wakeham D, Ketter T, Hooshmand F, Bjornstad J, Richards B, Westman E, Krauss RM, Saslow L
Psychiatry Res 2024 May;335:115866. Epub 2024 Mar 20 doi: 10.1016/j.psychres.2024.115866. PMID: 38547601
Prevention of suicide by clozapine in mental disorders: systematic review.
Masdrakis VG, Baldwin DS
Eur Neuropsychopharmacol 2023 Apr;69:4-23. Epub 2023 Jan 12 doi: 10.1016/j.euroneuro.2022.12.011. PMID: 36640481
Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial.
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
Asenapine for the Treatment of Psychotic Disorders.
Orr C, Deshpande S, Sawh S, Jones PM, Vasudev K
Can J Psychiatry 2017 Feb;62(2):123-137. Epub 2016 Aug 6 doi: 10.1177/0706743716661324. PMID: 27481921Free PMC Article
The MacCAT-T: a clinical tool to assess patients' capacities to make treatment decisions.
Grisso T, Appelbaum PS, Hill-Fotouhi C
Psychiatr Serv 1997 Nov;48(11):1415-9. doi: 10.1176/ps.48.11.1415. PMID: 9355168

Recent systematic reviews

Prevention of suicide by clozapine in mental disorders: systematic review.
Masdrakis VG, Baldwin DS
Eur Neuropsychopharmacol 2023 Apr;69:4-23. Epub 2023 Jan 12 doi: 10.1016/j.euroneuro.2022.12.011. PMID: 36640481
Cognitive behavioural therapy (group) for schizophrenia.
Guaiana G, Abbatecola M, Aali G, Tarantino F, Ebuenyi ID, Lucarini V, Li W, Zhang C, Pinto A
Cochrane Database Syst Rev 2022 Jul 12;7(7):CD009608. doi: 10.1002/14651858.CD009608.pub2. PMID: 35866377Free PMC Article
Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis.
Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235
Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis.
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R
BMC Psychiatry 2016 Oct 3;16(1):341. doi: 10.1186/s12888-016-1049-5. PMID: 27716110Free PMC Article

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